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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
18.79
Human Site:
T376
Identified Species:
41.33
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
T376
S
P
P
S
A
F
P
T
V
T
T
V
W
Q
D
Chimpanzee
Pan troglodytes
XP_519168
792
88529
T388
S
P
P
S
A
F
P
T
V
T
T
V
W
Q
D
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
P335
E
K
Q
D
S
P
P
P
K
P
P
R
T
R
S
Dog
Lupus familis
XP_540396
757
85032
T351
S
P
P
S
A
F
P
T
V
T
T
V
W
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
T375
S
P
P
S
A
F
P
T
V
T
T
V
W
Q
D
Rat
Rattus norvegicus
NP_476456
766
85965
S368
V
P
P
I
L
T
P
S
P
P
S
A
F
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
S348
I
L
T
P
S
P
P
S
A
Y
P
T
V
T
T
Chicken
Gallus gallus
XP_415970
1211
131521
Y797
T
P
S
P
P
S
A
Y
P
T
V
T
T
V
W
Frog
Xenopus laevis
NP_001084841
660
74123
V262
I
I
P
E
K
F
N
V
Y
S
L
I
Q
E
M
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
V172
Q
P
R
T
D
Y
C
V
R
T
L
T
V
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S409
G
K
P
S
K
D
A
S
H
P
S
S
S
K
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
6.6
100
N.A.
100
20
N.A.
6.6
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
20
100
N.A.
100
40
N.A.
20
20
33.3
33.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
37
0
19
0
10
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
10
0
0
0
0
0
0
0
0
37
% D
% Glu:
10
0
0
10
0
0
0
0
0
0
0
0
0
19
0
% E
% Phe:
0
0
0
0
0
46
0
0
0
0
0
0
10
0
10
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
19
10
0
10
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
19
0
0
19
0
0
0
10
0
0
0
0
10
0
% K
% Leu:
0
10
0
0
10
0
0
0
0
0
19
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
64
64
19
10
19
64
10
19
28
19
0
0
10
0
% P
% Gln:
10
0
10
0
0
0
0
0
0
0
0
0
10
37
10
% Q
% Arg:
0
0
10
0
0
0
0
0
10
0
0
10
0
10
0
% R
% Ser:
37
0
10
46
19
10
0
28
0
10
19
10
10
0
10
% S
% Thr:
10
0
10
10
0
10
0
37
0
55
37
28
19
10
19
% T
% Val:
10
0
0
0
0
0
0
19
37
0
10
37
19
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
37
0
10
% W
% Tyr:
0
0
0
0
0
10
0
10
10
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _